Immunoenhancement Effects of the Herbal Formula Hemomine on Cyclophosphamide-Induced Immunosuppression in Mice

Hemomine is an herbal blend comprising Angelicae Gigantis Radix and other herbs known to have immunomodulatory effects. We examined the immunopotentiating effect of this on cyclophosphamide (CPA)-induced immunosuppression. Male mice were assigned one six groups: intact control five CPA treatment groups (one control, reference (β-glucan), three with application hemomine at different concentrations; 4, 2, or 1 mL/kg; n = 10 per group). Mice injected induce myelosuppression immunosuppression, after which they received experimental treatments. In immunosuppressed mice, alleviated noticeable reductions in body, spleen, submandibular lymph node weights caused by CPA; changes hematological markers; induced reduced levels serum IFN-γ spleen TNF-α, IL-1β, IL-10 improved natural killer cell activities peritoneal cavity; also lymphoid organ atrophy a dose-dependent manner. demonstrate that hemomine, mixture herbs, effective agent, potential enhance immunity.